Blog of the Society for Menstrual Cycle Research

Understanding Research: Buyer Beware

April 2nd, 2012 by Paula Derry

xkcd.com // CC 2.5

I certainly believe that scientific research is important.  Research uncovers new knowledge and prunes away facts that are not accurate.  However, in our society, research is also a coinage to justify views of reality. A Biblical scholar might invoke a sentence from the Bible before holding forth on his own interpretation or opinions. In a similar manner, a scientific study might be cited or a scientist quoted to justify that something is real before jumping off into one’s own thoughts, opinions, theories, or justifications.  If a scientific result can be invoked, we can believe that something is true. Is there an unconscious?  Freud said so, but he’s out of date.  Are we intrinsically social beings?  Evolutionary theorists argue. Does meditation really result in an altered state of consciousness?  If I present results from research, preferably using a high tech measurement like a brain scan, or if I can come up with a theory that uses words like “neural nets” or “neurotransmitters,” then I can believe all of these things.

What’s wrong with this? Isn’t this science doing its job of uncovering truth?  There are two things wrong with this. One is that not all knowledge is scientific knowledge.  The second is that scientific results are often portrayed inaccurately in our society.

With regard to the first point, I’ll just give a few examples.  von Bertalanffy, a systems theory scientist, wrote that even a physicist will chase his (sic) hat when the wind blows it without knowing the mathematics determining which way the hat will blow.   Einstein famously said that not everything that was important could be measured, and not everything that could be measured was important.

But what I really want to talk about here is the second point.  We are inundated with scientific results in newspapers, websites, and other places. Most often, a brief summary of research is followed by broad generalizations about what the research means.   However, the outcome of research is not simple facts. Experiments are complicated things that must be evaluated by readers and understood in context.  When I was a graduate student in psychology, every class included practice in critiquing research.

To understand research, certain mathematical ideas are important.  “Statistical significance” is important to both accurate interpretation of research and to inaccurate or misleading reports. If you’ll bear with me, I’ll run through what I mean. Suppose you have a coin. If you toss the coin 100 times, it will come up heads about 50 times, not exactly 50 but close. Why?  That’s just the way the world we live in works, there are laws of probability. Since there are two possible outcomes—heads or tails—each will come up about half the time. If I toss my coin 100 times and it always comes up heads, I’ll probably conclude the coin is biased.  Why?  Because it just doesn’t happen; it’s extremely improbable, in the world we live in, that an honest coin would do this.

The woman, the serpent and the cycle

March 13th, 2012 by Chris Hitchcock

According to a recent study, women are best at picking out a picture with a snake during the days immediately before their period. You might think this would be a surprise, given the general idea of premenstrual compromise in women. Mind you, there isn’t much data to support poorer thinking or performance for women during the premenstrual period.

However, the authors were able to salvage the idea of premenstrual compromise here. They argue that about 30% of women have premenstrual syndrome, and most of the rest of us show some kind of cyclicity. And so they attribute the 200 millisecond (1/5 of a second) faster response to anxiety and fear. Either that, or it is maternal instinct, protecting the small cluster of cells that might possibly be an impending pregnancy.

Media has picked this up, with headlines about PMS being good for something after all.

Sometimes it seems that women can’t win for losing.

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Badass Baristas and PMS Superpowers

August 25th, 2011 by Elizabeth Kissling

Crimson Tide, a.k.a. Cassie Taylor (Super Power: Epic Rage)

Are you following the PMS Adventures of Crimson Tide, Maxi Pad, and Tam Pon? After a paid medical trial went bad, these ladies developed extraordinary superpowers that manifest only when they’re menstruating — and since they’re roommates, their cycles are often synchronized.

Start here to read an abridged version of their origin story and follow the links to catch up on all of their adventures.

[via LunaGal]

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We’re back!

July 27th, 2011 by Elizabeth Kissling

Tap, tap.

Is this thing working? Is this thing on?

After some rest, reconnaissance, and re-organization, re:Cycling is back — bigger, bolder, and with more menstruation and women’s health news than ever. Most of our old team is back, along with a few new recruits and some exciting guest bloggers. There’ll be some new features here as well. More about all of that is coming soon. Our posting will be spotty and irregular throughout August, but expect to see a more consistent, regular flow after September 1. (Yeah, see what I did there? )

We’ve missed a lot of action in four months away. We can’t possibly summarize all of it, but here are some of my personal highlights:

 

July 19 – The Institute of Medicine (U.S.)  just released a report on preventive health services for women, and the consensus is that health plans under the Patient Protection and Affordable Care Act (ACA) of 2010 should cover contraception without demanding co-payments. You can read and/or download the full report here.

 

July 18 – Remember Summer’s Eve marketing disaster last summer? They still don’t get it. This year’s “Hail to the V” campaign may be saluting vaginas, but it’s still telling everyone vaginas are dirty.

As Maya put it over at Feministing.com,

That chatty hand claims to be my vagina but is clearly an impostor, because my vagina would never refer to herself as a “vertical smile,” knows better than to even mention vajazzaling to me, and is too busy complaining about how long it’s been since she’s gotten laid to give a damn about if my cleansing wash is PH-balanced. My vagina is not a whiny little pussy.

If you’re not offended enough, check out the stereotypes in the Black and Latina vaginas. For a satisfying satirical response, check out Stephen Colbert’s July 25 program.

 

July 13 – Bloggers at Ms. magazine have done yeoman work drawing attention to the sexism in the latest PSA from the milk industry, criticizing the sexism toward both women and men in the Milk Board’s stereotype-rich “Everything I Do Is Wrong” campaign about PMS. Ms. has also promoted Change.org’s petition protesting the campaign. Update: By July 24, the campaign had been pulled in response to protests.

2011 Ad for Always brand maxi padJuly 5 – As copyranter astutely notes, the use of a RED spot in the center of a maxi-pad to represent menstrual blood is an historic moment in advertising history. Are we finally done with the mysterious blue fluid? (By the way, copyranter is THE source for smart, snarky analysis of advertising;  he oughta know — his day job is writing the stuff.)

 

June 20 – Corporate and subsidized donations of disposable menstrual pads may be good for girls, but not so good for the environment.

 

June 2 – British artist Tracey Emin  art student at University of Wisconsin, follows in Judy Chicago’s inspirational footsteps and turns her tampons into art.

 

What else have we missed? Add your links in the comments, and don’t be shy about sending us suggestions!

 

 

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Herbal treatments for PMS — what works?

February 7th, 2011 by Elizabeth Kissling

Given the variety of symptoms of PMS (more than 150), it’s not surprising that no single treatment is effective for all cases, or that women would seek remedies in alternative medicine. A new review of 30 years of literature on herbal remedies sought to discover if randomized clinical trials (RCTs) on these alternatives found any of them effective. However, of the 102 articles identified, only 17 were RCTs and only 10 were included in the study: the researchers report that “the heterogeneity of population included, study design and outcome presentation refrained from a meta-analysis.” Based on this limited study, here are the findings:

Vitex agnus castus was the more investigated remedy (four trials, about 500 women), and it was reported to consistently ameliorate PMS better than placebo. Single trials also support the use of either Gingko biloba or Crocus sativus. On the contrary, neither Evening primrose oil nor St. John Worth show an effect different than placebo. None of the herbs was associated with major health risks, although the reduced number of tested patients does not allow definitive conclusions on safety.

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Sex, Lies and Pharmaceuticals

December 16th, 2010 by Chris Hitchcock

There’s a new book about the intimate role of the pharmaceutical industry in the construction of diseases, using the example of FSD (female sexual dysfunction). The authors are Ray Moynihan, an Australian investigative journalist with a longstanding interest in this topic, and Barbara Mintzes, Assistant Professor in the Department of Pharmacology & Therapeutics at the University of British Columbia. I haven’t yet seen the book, but listened to the webinar, which is now available on the Canadian Women’s Health Network (CWHN) website.

There were a few things that struck me. One is how blatant the interference of the pharmaceutical industry can be. For example, the webinar includes a reference to an email sent to Lenore Tiefer letting her know that a formative 1997 meeting about female sexual dysfunction was only open to those who were either part of or willing to work with the pharmaceutical industry. Another was the way in which the language about the medical understanding of the cause of FSD tracked the introduction of 3 different potential drugs, each with different targets and different mechanisms. So far, each drug has failed in clinical trials.

The medicalization of human sexuality separates our bodies from our emotional lives, and creates a framework within which emotional or relationship difficulties are seen as being caused by the biological, rather than being interdependent. And little attention is paid to the ways in which pharmaceutical cures may even create relationship problems that were not there before.

There are, of course, parallels with other cases. For example, the idea that menopausal is a hormone deficiency disease makes it much easier to argue that every healthy menopausal woman should take hormone replacement therapy. This replacement language is unfortunately still alive and well in both medical and popular usage.

Another parallel is the construction of “premenstrual syndrome” into a psychiatric diagnosis. This has been provisionally incorporated into the Diagnostics and Statistics Manual (DSM) of the American Psychiatric Association, initially as “Late Luteal Dysphoric Disorder”, now “Premenstrual Dysphoric Disorder”. Among other things, this construction supported the repackaging and marketing of Prozac as Sarafem for this newly created psychiatric disorder, extending the marketability of Prozac beyond its patent expiry date.

The APA is currently working on DSM V, to be published in May, 2013, and there is an opportunity for activism. So far, PMDD is listed in the “needs more research” section. But chances are it will be put forward again for the next edition.

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PMS Is Not Universal

December 14th, 2010 by Elizabeth Kissling

images(3)Not only does PMS not turn women into Vikings, heavyweight boxers, or Mexican wrestlers (see yesterday’s post about ads for Kitadol), it does not affect every woman who menstruates. Research using daily surveys to examine patterns of depression and anxiety symptoms in young women found that some women experience symptoms mid-cycle, others pre-menstrually, and still others do not experience mood changes in association with their menstrual cycle.

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PMS, Chocolate, and Other Stereotypes

November 12th, 2010 by Elizabeth Kissling

Screen_Shot_of_PSM-SOSThere’s already more than 60 apps on the market for tracking PMS and other aspects of the menstrual cycle, but there always room for one more: Betty Crocker introduced the PMS SOS app this week. In addition to sad stereotypes about gender and how women are ruled by their hormones, this app gives you coupons for discounts on General Mills baking products.

PMS SOS is so over-the-top it’s this week’s deserving prize winner of Bitch magazine’s Douchebag Decree. I really can’t add anything to their remarks but applause.

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Because women aren’t medicated enough?

September 19th, 2010 by Elizabeth Kissling

ProzacSome of you may recall that in my book, Capitalizing on the Curse, I argued that the addition of PMDD to the DSM-IV and the re-branding of fluoxetine HCI as Sarafem are linked. It was no coincidence that pharmaceutical manufacturer Eli Lilly sought a unique FDA approval for Sarafem as treatment for PMDD just as the patent on Prozac, also composed of fluoxetine HCI, was about to expire. Eli Lilly initially secured the patent for Sarafem until 2007, and it is no longer the only FDA-approved treatment for PMDD.

Lilly must be in need of a new way to keep milking the cash cow. How fortunate that new research suggests that Prozac can relieve garden-variety PMS as well. A neuroscientist at the University of Birmingham presented research last week at the British Science Festival that asserts a 2mg daily dose of fluoxetine in the week before menstruation could alleviate PMS. She tested it for three years on rats. Of course, rats don’t actually experience PMS, so they were “induced to have PMS-like symptoms”.

Every time I read another article about new treatments for PMS, I remember Joan Chrisler’s comments about over-diagnosis of PMS and PMDD (which are both associated with high levels of relationship and family stress): “We’re conditioned to want a pill. Instead of something you might need more, like a nap or a divorce, or the ERA.”

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Napping is Good for You!

April 28th, 2010 by Elizabeth Kissling
The Importance of Nap Time by Age, graph by cmoney345

The Importance of Nap Time by Age, graph by cmoney345

This is a very small study, but I don’t need much encouragement for an afternoon nap. Researchers wanted to test whether a mid-afternoon nap during the late-luteal phase of the menstrual cycle (commonly known as the premenstrual period) would improve symptoms of sleepiness, mood, and cognitive performance without negatively impacting subsequent nocturnal sleep. They tested this hypothesis on ten women with significant premenstrual symptoms and a control group of nine women with minimal or no symptoms, and found that napping made both groups feel better. More precisely,

Napping improved sleepiness, alertness, mood, and some aspects of cognitive performance. Improvements were maintained for at least 30 minutes and up to 6 hours after napping. An afternoon nap benefited both groups of women, but those with significant symptoms had a slightly greater improvement in intensity of mood 30 minutes after the nap.

Napping – it’s not just for kindergarteners. Wouldn’t the world be a better place if everyone could have a Fig Newton and a blankie at about 2:30 pm?

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Is PMDD Genetic?

March 9th, 2010 by Elizabeth Kissling

White lab mouse sitting in a gloved palm.

Guest Post by Amber Steele, University of Cambridge

There have been a couple of stories in the press recently touting a study by Joanna Spencer and colleagues suggesting that PMDD may be genetic. I had a cursory look through the paper and read the article. Changes in dendritic branching of neurons in the limbic system across the menstrual cycle, owing to changes in estrogen, has been well documented in the female mice and rat. Additionally, changes in neuronal activity and accompanying receptor activity is also well document during periods of hormone change, again in the female mice and rat models. Individual differences in how this change occurs and the fact that it can be linked to differences in genes make sense. It seems that Spencer et al., have identified one of probably many genes that mediates these differences. This is not the first time that a gene of this kind has been identified or implicated. For example, Susan Girdler at Chapel Hill has done some interesting work on PMDD and suggests a genetic i.e., differing protein response to a hormone, difference in response to progesterone that might, in part, explain symptoms associated with PMDD.

The fact that Spencer et al., found a relationship to anxious behavior does not say anything conclusively about PMS or PMDD. It only states that if you have this variant then your levels of anxiety may change as estrogen fluctuates.

The news article is exploiting the findings from the Spencer study to construct a simplistic view of varying responses to hormone change within and across women. I suppose the author of the news article thought it might be interesting to examine the debate on whether or not there is a “clinically disordered” state during the luteal phase of the menstrual cycle in some women and whether it should be recognized officially. While it may do this, it also perpetuates misunderstandings and stereotypes about women’s hormones and their emotional states.

Amber Steele is a graduate student at the University of Cambridge with a biomedical background. She is writing a thesis is on wellbeing over the menstrual cycle and how it relates to hormonal “biomarkers” cortisol and progesterone.

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Because nothing is funnier than PMS

February 19th, 2010 by Elizabeth Kissling

Print ad for Kitadol Período Menstrual (PMS medication)Ha ha! It’s funny because PMS turns women into hideous monsters! Just like Mexican wrestlers! Get it?

Yeah, I’m not laughing either at this ad for Kitadol. Neither is Copyranter.


[via Glad Rags]


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Readers should note that statements published in re: Cycling are those of individual authors and do not necessarily reflect the positions of the Society as a whole.