Blog of the Society for Menstrual Cycle Research

Another Risk Associated with Hormone Therapy

February 7th, 2010 by Elizabeth Kissling

A study to be published in the British Medical Journal’s Thorax,* which focuses on respiratory medicine, finds that estrogen-only hormone treatment for menopause symptoms is associated with higher risk of asthma. The study involved nearly 58,000 women over 12 years. The researchers compared women who had never used any form of hormone treatment, women who used estrogen plus progestin, and women who used estrogen only treatment.Cartoon drawing of human lungs

The women who had used hormone treatments were 21% more likely to develop asthma; those who had used estrogen-only treatments showed a 54% higher overall risk of asthma.

Asthma is generally more common in young women after menarche, and more severe in women than in men.

*Neither the study nor the abstract appear to be available online.

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Newsflash: Women get older with or without hormone therapy

January 5th, 2010 by Elizabeth Kissling

Cover of journal MENOPAUSEAs we have often noted here, one of the key reasons the marketing of hormone therapy for menopausal women has been so successful is the misguided belief that menopause is an estrogen-deficiency disease. Among other purported disadvantages of the decline in estrogen that accompanies normal aging was the belief that this decline caused muscle loss and other declines in physical functioning. (Muscle cells have receptors for estrogen, and recent research has linked higher blood levels of the hormone to greater muscle strength in elderly women.)

But the Women’s Health Initiative (WHI) is still providing new information about the lack of benefits of HT. (For those who are new around here, the WHI is a large US clinical trial begun in 1991, in which thousands of postmenopausal women were randomly assigned to take either HT or placebo pills. The study was abruptly ended ahead of schedule in 2002, when researchers discovered that the women taking the hormones had higher risks of heart attack, stroke, breast cancer, and blood clots – the very conditions the drugs were assumed to prevent – than placebo users.) In a new study based on a subgroup of 2400 women to be published in a forthcoming issue of Menopause (February 2010), both the women using HT and the placebo groups showed similar dips in muscle strength and walking speed over six years. In other words, women get older and show physical indications of aging with or without hormone therapy.





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Bioidentical Balderdash

January 1st, 2010 by Chris Hitchcock

The bioidentical hormone therapy industry has been getting a bad rap lately in the US, and this press release is an example of why. Among other things, the writer confuses estrogen and progesterone, in one paragraph saying their product is a “safe and scientifically-proven, all-natural estrogen delivery cream[]“, and in the next describing it as a “natural progesterone cream” (emphasis is mine). Moreover, the press release springboards from another estrogen-positive press release that claims that estrogen may be the cure for female depression, citing an ob/gyn author of a book, and promoting a soon-to-be-launched web page.

So, in one breath the product is an estrogen delivery cream that will help with low estrogen, but in the next breath (on the linked product page) it is argued that it will help with estrogen that is too high (which is more accurate). The product website emphasizes that  it is “without dangerous pharmaceuticals”:

This remarkable product contains NO risky synthetic estrogens or progestins. [Product] Cream is similar to the progesterone your body naturally produces, so there are no worries about dangerous interactions or nasty side effects.

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