Blog of the Society for Menstrual Cycle Research

How much blood is too much?

January 24th, 2011 by Elizabeth Kissling

The US Food and Drug Administration (FDA) approved tranexamic acid tablets as treatment for heavy menstrual bleeding more than a year ago, but you probably haven’t seen much of this television commercial to promote the drug (brand name Lysteda). Matthew Arnold reports in Medical Marketing and Media that television network executives are put off by the ad’s explicit mention of “periods” and “bleeding” combined with the symbolism of fall red rose petals.

(The article appeared in the December, 2010, print issue of MMM, but online October 20, 2010.)

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Clinical Trials for Lysteda

October 11th, 2010 by Elizabeth Kissling

Nearly a year ago, we shared news of FDA approval of tranexamic acid tablets as treatment for heavy menstrual bleeding. Today we learned of successful clinical trials of the drug this purpose: The current issue of Obstetrics & Gynecology includes the results of a double-blind placebo-controlled study of tranexcmic acid tablets, in which the drug “was well tolerated and significantly improved both menstrual blood loss and health-related quality of life in women with heavy menstrual bleeding.”

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Teens and the IUD

July 8th, 2010 by Elizabeth Kissling


Art by Flickr user Buhny | CC 2.0

Art by Flickr user Buhny | CC 2.0

A new study published in the Journal of Obstetrics and Gynecology has found that adolescents are usually able to tolerate the Mirena® IUD rather well. The mean age of girls in this British study was 15.3 years, and they were prescribed the Mirena® for painful and/or heavy periods that did not respond to oral medications. 93.4% of girls in the study (45 young women) reported “significant improvement” within four months. The researchers conclude “that Mirena is a well tolerated and effective alternative for heavy periods±dysmenorrhoea in adolescents who do not respond to oral therapy.”


So will this finding make it easier for young women to obtain an IUD if they’d like it for birth control, now that there is evidence that it is well tolerated?

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Period Sex is a Bloody Good Time (says college newspapers)

January 4th, 2010 by Elizabeth Kissling

Back in November, we commended a bold student columnist for taking on menstrual sex in the student paper at Chico State University. In yesterday’s edition of The Faster Times, columnist Veronica Mittnacht advises a reader about how to broach the subject of period sex in a casual relationship, and works to normalize menstruation – even heavy flow.

Fortunately, most men, even if they don’t really like it [menstruation], know enough to pretend not to mind, because, after all, most women do it, and there’s not much men can do about it.  And for your purposes, for now, pretending is enough. There’s still the occasional guy who can’t handle blood, but the bell curve compensates by giving us the occasional fetishist or enthusiast to make up for it.

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The cure for all things menstrual?

December 24th, 2009 by Chris Hitchcock

A recent press release from the American College of Obstetricians and Gynecologists announces that Hormonal Contraceptives Offer Benefits Beyond Pregnancy Prevention. This is in the same vein as similar articles published over the years about “non-contraceptive benefits of the pill” – a laundry list of the many benefits women may obtain by using hormonal contraception. It’s not clear how they should be used by practicing obgyn’s. One use is certainly as additional talking points to convince women who are cautious or reluctant to replace their body’s own menstrual physiology with a pharmaceutical product.

I haven’t been able to read the full document (for some reason my university access seems to only find the first page of the full document), but it appears that, like previous reviews I have read, it is a biased list, including benefits but not risks. Perhaps what is most in common is the sense that a spontaneous menstrual cycle is somehow suspect, that fluctuations over time are unnatural, and that pharmaceutical control is a good solution.

I can understand why the pharmaceutical industry might want to publish a long list of off-label uses (although they would be quickly stopped by the US’s FDA and regulatory bodies in other countries). But it is a curious thing to find a professional group extolling the many off-label benefits of a class of pharmaceutical drugs. Do cardiologists publish practice bulletins about the non-cardiovascular benefits of statins?

There are other perspectives about how one might treat painful periods or heavy menstrual flow. The published Cochrane Reviews (well-respected summaries of published studies) about cramps suggest that the evidence for non-steroidal anti-inflammatories (NSAIDS, such as ibuprofen) is more solid and clear than that for combined oral contraceptives, and that, to date, no studies have compared them head-to-head. Moreover, NSAIDs also have been shown to reduce menstrual flow.

The press release notes the protective effects against endometrial, ovarian and colorectal cancer, but fails to note the increased risk of sexually transmitted infections. Being on the pill is the most important risk factor for not using condoms.

And when absent or long periods occur, inducing regular and predictable flow will reduce the risk of endometrial cancer, but otherwise primarily serves to mask the underlying issue. In that case, going on the pill can be like hitting snooze on your smoke alarm.

 

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Readers should note that statements published in re: Cycling are those of individual authors and do not necessarily reflect the positions of the Society as a whole.